MTHFR C677T and MTR A2756G polymorphisms and the homocysteine lowering efficacy of different doses of folic acid in hypertensive Chinese adults
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چکیده
منابع مشابه
MTHFR C677T and MTR A2756G polymorphisms and the homocysteine lowering efficacy of different doses of folic acid in hypertensive Chinese adults
BACKGROUND This study aimed to investigate if the homocysteine-lowering efficacy of two commonly used physiological doses (0.4 mg/d and 0.8 mg/d) of folic acid (FA) can be modified by individual methylenetetrahydrofolate reductase (MTHFR) C677T and/or methionine synthase (MTR) A2756G polymorphisms in hypertensive Chinese adults. METHODS A total of 480 subjects with mild or moderate essential ...
متن کاملAuthor's response to reviews Title: MTHFR C677T and MTR A2756G Polymorphisms and the Homocysteine Lowering Efficacy of Different Doses of Folic Acid in Hypertensives Chinese Adults Authors:
Xianhui Qin ([email protected]) Jianping Li ([email protected]) Yimin Cui ([email protected]) Zeyuan Liu ([email protected]) Zhigang Zhao ([email protected]) Junbo Ge ([email protected]) Deming Guan ([email protected]) Jian Hu ([email protected]) Yanni Wang ([email protected]) Fumin Zhang ([email protected]) Xin Xu ([email protected]) Xiaobin Wang ([email protected]) Xiping...
متن کاملHomocysteine Metabolism Gene Polymorphisms (MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) Jointly Elevate the Risk of Folate Deficiency
Folate deficiency is strongly associated with cardiovascular disease. We aimed to explore the joint effect of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MTR) A2756G, and methionine synthase reductase (MTRR) A66G polymorphisms on folate deficiency in a Chinese hypertensive population. A total of 480 subjects aged 28-75 were enrolled in this study from ...
متن کاملRole of MTHFR C677T and MTR A2756G polymorphisms in thyroid and breast cancer development.
Folate metabolism is essential for DNA synthesis and repair. Alterations in genes that participate in folate metabolism can be associated with several types of malignant neoplasms, including thyroid and breast cancer. In the present case-control study, we examined the association between methylenetetrahydrofolate reductase (MTHFR C677T, rs1801133) and methionine synthase (MTR A2756G, rs1805087)...
متن کاملRole of C677T and A1298C MTHFR, A2756G MTR and -786 C/T eNOS Gene Polymorphisms in Atrial Fibrillation Susceptibility
BACKGROUND Hyperhomocysteinemia has been suggested to play a role in the NonValvular Atrial Fibrillation (NVAF) pathogenesis. Polymorphisms in genes coding for homocysteine (Hcy) metabolism enzymes may be associated with hyperhomocysteinemia and NVAF. METHODOLOGIES 456 NVAF patients and 912 matched controls were genotyped by an electronic microchip technology for C677T and A1298C MTHFR, A2756...
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ژورنال
عنوان ژورنال: Nutrition Journal
سال: 2012
ISSN: 1475-2891
DOI: 10.1186/1475-2891-11-2